Exploiting p53 Status to Enhance Effectiveness of Chemotherapy by Lowering Associated Toxicity
نویسندگان
چکیده
Linda S. Steelman1, Alberto M. Martelli2,3, Ferdinando Nicoletti4, and James A. McCubrey1 1 Department of Microbiology & Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858 USA 2 Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell’Apparato Locomotore, Università di Bologna, Bologna, Italy 3 IGM-CNR, Sezione di Bologna, C/o IOR, Bologna, Italy 4 Department of Biomedical Sciences, University of Catania, Catania, Italy
منابع مشابه
Evaluating the Toxicity of Doxorubicin-Silk Fibroin Nanoparticles and Its Effect on P53 Gene Expression in Breast Cancer Cell Line
Introduction: The use of drug delivery systems can increase the effectiveness of chemotherapy and reduce its side effects in the treatment of breast cancer. This study aimed to evaluate the effect of doxorubicin-containing silk fibroin nanoparticles (NF-DOX) on P53 gene expression in breast cancer cell lines and to measure its toxicity in vitro. Methods: NF-DOX was synthesized and characterize...
متن کاملAnti-cancer Potential of Captopril and Botulinum Toxin Type-A and Associated p53 Gene Apototic Stimulating Activity
Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic ef...
متن کاملAnti-cancer Potential of Captopril and Botulinum Toxin Type-A and Associated p53 Gene Apototic Stimulating Activity
Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic ef...
متن کاملکاپتوپریل و پاراکوات در بیان ژن و پروتئین p53 و Bcl-2 در نمونه‌های بافت ریه موش صحرایی: روش RT-PCR و ایمونوهیستوشیمی
Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal" mso-tstyle-rowband-size:0 mso-tstyle-colband-size:0 mso-style-noshow:yes mso-style-priority:99 mso-style-qformat:yes m...
متن کاملRelation between Estrogen and Progesterone Receptor Status with p53, Ki67 and Her-2 Markers in Patients with Breast Cancer
Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2011